Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes
نویسندگان
چکیده
منابع مشابه
Tumor regression following intravenous administration of lactoferrin- and lactoferricin-bearing dendriplexes
UNLABELLED The possibility of using gene therapy for the treatment of cancer is limited by the lack of safe, intravenously administered delivery systems able to selectively deliver therapeutic genes to tumors. In this study, we investigated if the conjugation of the polypropylenimine dendrimer to lactoferrin and lactoferricin, whose receptors are overexpressed on cancer cells, could result in a...
متن کاملEnhanced gene expression in the brain following intravenous administration of lactoferrin-bearing polypropylenimine dendriplex.
The possibility of using gene therapy for the treatment of brain diseases such as brain cancer, Alzheimer's and Parkinson's diseases, is currently hampered by the lack of gene delivery systems able to cross the blood-brain barrier and deliver DNA to the brain following intravenous administration. On the basis that lactoferrin can effectively reach the brain by using specific receptors for cross...
متن کاملPharmacokinetics and Biodistribution of Rhopalurus junceus Scorpion Venom in Tumor-Bearing Mice after Intravenous and Oral Administration
Introduction: Rhopalurus junceus scorpion venom has shown potential for anticancer treatment. However, there are no scientific evidence about venom pharmacokinetic (PK) and biodistribution (BD) in tumor-bearing mice. Methods: 131I-labeled venom was administrated by intravenous (IV) and oral (PO) routes at the single dose of 12.5 mg/kg. Mice were sacrificed and blood samples, major organs, and t...
متن کاملPharmacokinetics of Cefepime Following Intravenous and Intramuscular Administration in Sheep
Normal 0 false false false MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0c...
متن کاملAntibacterial activity of Lactoferrin and Lactoferricin against oral Streptococci
Lactoferrin (Lf) is an iron-binding glycoprotein which exhibits antibacterial activity against a broad range of Gram-negative and Gram-positive bacteria. The mechanisms of this property are complex and involve iron sequestration as well as direct interaction with bacteria. Lactoferricin (LFcin), a Lf-derived peptide released by pepsin digestion of lactoferrin, is a more potent antibacterial com...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanomedicine: Nanotechnology, Biology and Medicine
سال: 2015
ISSN: 1549-9634
DOI: 10.1016/j.nano.2015.04.006